The Potential Budget Impact of PCSK9 Inhibitors in Ireland

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15 صفحه اول

PCSK9 Inhibitors

Alirocumab and evolocumab are monoclonal antibodies that block proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating protein that degrades low-density lipoprotein (LDL) receptors. These therapies increase LDL receptors on the cell surface and reduce plasma LDL cholesterol. Both therapies are approved to lower LDL cholesterol, a causative agent for atherosclerotic cardiovascular d...

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ژورنال

عنوان ژورنال: Value in Health

سال: 2016

ISSN: 1098-3015

DOI: 10.1016/j.jval.2016.09.1710